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Relative to either monotherapy, the greater OHIP14 K reduction at week 4 indicates a faster onset of benefit and clarifies that the combination confers speed rather than sustained superiority

10.2174/1570159X22666231103085859 Summary Keywords deuterium, copper, histidine, amyloidogenic proteins, cardiolipin, mitochondrial dysfunction, neurodegeneration Citation Seneff S and Kyriakopoulos AM (2025) Deuterium trafficking, mitochondrial dysfunction, copper homeostasis, and neurodegenerative disease

Conclusion This is the first report of intravesical BPC-157 (10 mg) injection to help patients with moderate to severe interstitial cystitis who did not respond to pentosan polysulfate treatment

The possible adverse reactions reported with oral tranexamic acid therapy are abdominal bloating, headache, and menstrual irregularities that are rare and transient (Lee et al., 2016a)