It occurs in three biological contexts with different functional consequences: type 1 EMT is involved in embryonic development and growth [52], type 2 EMT is involved in wound healing, tissue regeneration, and fibrosis [52], and Type 3 EMT, also known as oncogenic EMT, contributes to cancer metastasis [52,53,54,55]
Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging
In mice, the bulk of the metabolic improvement seen upon FGF21 treatment derives from centrally mediated weight loss, whereas FGF21 analogs elicit limited weight loss in humans
Lachowiez C, DiNardo CD, Takahashi K, Loghavi S, L-C X, Kadia TM, Daver N, Adeoti M, Short NJ, Sasaki K, Wang SA, Borthakur G, Issa GC, Maiti A, Alvarado Y, Pemmaraju N, Montalban-Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Garcia-Manero G, Kornblau SM , Ravandi F, Jabbour EJ, Konopleva M, Kantarjian H
