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Cumulative effects of therapies on disability in relapsing multiple sclerosis

Exercise-Induced Oxidative Stress Intense or prolonged exercise generates substantial oxidative stress through increased oxygen consumption and metabolic rate, increased mitochondrial electron leakage producing reactive oxygen species, recruitment of inflammatory immune cells to exercising muscles, and mechanical stress on tissues producing oxidative damage

DMEM with or without H 2 O 2 was introduced into the ATDC5 cell cultures, followed by incubation with varying concentrations of metformin for 24 h to discern the effect of metformin on the cells

These findings provide a theoretical basis for developing drug delivery strategies targeting butyrate transport systems