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HPLC (High-Performance Liquid Chromatography) is used to verify peptide purity and detect impurities that may affect experimental results

Although MAPT mutations are not specifically associated with AD, tau tangles are a key hallmark of the disease, and in humans the number of neurofibrillary tangles correlates with cognitive decline and neurodegeneration better than A plaques (Giannakopoulos et al., 2003)