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Dysregulation of TNF alpha is involved in the pathogenesis of numerous inflammatory conditions, most notably rheumatoid arthritis, inflammatory bowel disease, psoriasis vulgaris and psoriatic arthritis

Conclusion and future perspectives As shown in the Figure 4 , cysteine has different fates including the synthesis of cysteine-derived molecule, sulfur/carbon metabolic reprogramming, and venue for post-translational protein modification of various proteins or discovery of drug inhibitors

This should, however, be read in the context of the earlier reservations: it concerns observations from cultures and animal models, not a clinical assessment