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Administration of IGF-I down-regulates proteolysis but does not appear to alter protein synthesis (Hussain, Schmitz, Mengel et al., 1994)

By highlighting both mechanistic insights and translational advances, the review article outlines how next-generation engineered peptide therapeutics, used alone or in combination with existing disease-modifying agents, may help reshape the future landscape of AD diagnosis, prevention, and treatment

Elevated iron levels increase macrophage secretion of matrix metalloproteinases, degrading the ECM and inducing AS plaque rupture

There are risks associated with any treatment procedure and individual results may vary