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In contrast to rodents, IGF-1 levels in humans are usually not reduced with chronic CR unless protein is also restricted 103 (see below)

2 Vitamin B12induced acne can be differentiated from acne vulgaris by the presence of pruritus, correlation between drug use and eruption, sudden onset, patient age, and the absence of comedones and microcysts

Acknowledgements This study/project was funded by the NIHR Invention for Innovation programme (grant number NIHR200022)

Middha P, Weinstein SJ, Mnnist S, Albanes D, Mondul AM (2019) -carotene supplementation and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: the role of tar and nicotine