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This is particularly relevant for injectable formulations obtained outside standard pharmaceutical channels, where risks of contamination, endotoxin exposure, or improper compounding may exceed any theoretical biologic effect

Among pen users in one study, 22.2 percent achieved optimal glycated hemoglobin levels compared to just 2.2 percent among syringe users, a statistically significant difference driven largely by better adherence

And, it wasnt until the 1960s and 70s that pharmacological treatments began to gain traction, particularly for opioid use disorder (OUD)

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