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Overall conclusions Cumulative event rates from the primary outcome (fatal chronic heart disease (CHD) or non-fatal myocardial infarction (MI)) of the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) treatment group, have demonstrated that because of the superiority of thiazide-type diuretics in preventing one or more major forms of cardiovascular disease (CVD) and their lower cost, they should be the drugs of choice for first-step antihypertensive drug therapy

Frye RE, Slattery J, Delhey L, Furgerson B, Strickland T, Tippett M, Sailey A, Wynne R, Rose S, Melnyk S, Jill James S, Sequeira JM, Quadros EV

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