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in vitro testing, large agglomerates of 17 nm TiO 2 caused stronger toxicity responses including glutathione depletion, IL-8 and IL-1 increase, and DNA damage in monocytic cell lines, compared to small agglomerates

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In this aspect, the sKlotho level is assumed as a prognostic biomarker for adverse clinical outcomes in this population (Liu et al., 2019a)

Vascular dysfunction is recognized to be part of the pathogenesis of several retinal pathologies, such as diabetic retinopathy (DR), age-related macular degeneration (AMD), retinal vessel occlusion, retinopathy of prematurity and glaucoma [41]