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In a study in the 5XFAD mouse model of AD, microbial dysbiosis was noted to be associated with activation of the endolysosomal CCAAT/enhancer-binding protein- (C/EBP-) asparagine endopeptidase (AEP) pathway (Chen et al., 2020)

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VIP, a 28-amino acid peptide, exhibits a diverse range of biological activities due to its interactions with multiple G protein-coupled receptors (GPCRs) from the VIP/PACAP receptor family (Harmar et al., 2012)

This blend is commonly studied in experimental models focused on peptide interaction, multi-pathway signaling, and compound behavior within combined research systems