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Lower SASP secretion (less inflammatory cytokines, proteases) improved tissue microenvironment

In addition, during the early years of stage 3 and later years of stage 2, the least progression in UPDRS score is observed, which is 0.072 on average

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Research has shown increased phosphorylation of extracellular signal-regulated kinases (ERK) 1 and 2, along with their downstream targets, including c-Fos, c-Jun, and Egr-1, which are molecules involved in cell growth, migration, and angiogenesis