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The binding of T3 to TRs induces a conformational change in the receptor, which allows the receptor to bind to thyroid hormone response elements (TREs, specific DNA sequences) in the promoter regions of target genes (Simons 2003)

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Nucleic acid drugs (NADs) are a new generation of gene-editing modalities characterized by their high efficiency and rapid development, which have become an active research topic in new drug development field