l-carnitine side effect fishy body odor Stabilizing the enzyme in fish syndrome Revisiting the Role of Carnitine

ACS Nano 2019 , 13 , 39103923

Peptide sequence: NleAspHisDPheArgTrpLysNH2 (often written as NleAsp(1)HisDPheArgTrpLys(1)), incorporating nonnatural residues and a cyclic backbone to resist enzymatic degradation and prolong biological activity in preclinical models

Short N, Kantarjian H, Ravandi F, Huang X, Jain N, Sasaki K, Khouri R, Daver N, Pemmaraju N, Khoury J, Jorgensen J, Alvarado Y, Konopleva M, Garcia-Manero G, Kadia T, Yilmaz M, Borthakur G , Burger J, Kornblau S, Wierda W, DiNardo C, Ferrajoli A, Jacob J, Rostykus M, Garris R, Ward M, Huang B, Encarnacion C, Loiselle C, O'Brien S, Jabbour E

This gas then allows the cell to better regulate the oxidative stress often caused by these conditions, which eventually results in inflammation that can kill the cell