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Hypothalamus is known as the control panel of large numbers of hormones, hypothalamic releasing and inhibiting hormones such as corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone (TRH), growth hormone-releasing hormone, somatostatin (SS), also called growth hormone-inhibiting substance, gonadotropin-releasing hormone (GnRH), dopamine, etc

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A number of dosage protocols appear in the epithalamin and epithalon studies and trials performed to date, the most notable of which has been the Khavinson protocol (or, Russian protocol) for anti-aging and longevity [1]