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While glutamate is typically abundant in the standard human diet, cysteine and glycine are frequently depleted, especially during times of chronic metabolic stress, severe viral infection, or the natural aging process

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Am J Gastroenterol 92:13391341 McCafferty DM, Miampamba M, Sihota E, Sharkey KA, Kubes P (1999) Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice