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However, this function can be compromised during copper overload, as Cu binding to the cysteine residues of GPX4 promotes its ubiquitination and autophagic degradation, thereby disrupting lipid peroxide metabolism and sensitizing cells to ferroptosis [65]

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Table 2 Oncogenes and tumor suppressor genes regulate tumor Gln metabolism

Seeing your dentist promptly if any concerning signs arise is especially important for those at greater risk