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The PICOs elements were defined as follows: P (Participants): subjects of any age diagnosed with Vitamin B12 deficiency

GHK-Cu, by contrast, is primarily investigated as a copper-binding signaling peptide that influences gene expression pathways associated with extracellular matrix remodeling and collagen regulation

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He pulled together findings from journals such as Gastrointestinal Endoscopy, Current Pharmaceutical Design, Expert Opinion on Biological Therapy, and Wound Repair and Regeneration