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Lancet Oncol 15(10):e447e460 Martnez ME, Jacobs ET, Baron JA, Marshall JR, Byers T (2012) Dietary supplements and cancer prevention: balancing potential benefits against proven harms

[] The three D-penicillamine functional groups (thiol, amino and carboxyl groups) are shown in Figure 6 and they are responsible for its distinctive chemical reactions among which is its metal-chelating ability

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This approach mirrors how longevity-focused clinicians use other interventions, prioritizing a sustained, low-amplitude signal over a short, high-amplitude intervention