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The study suggests that HK2 is typically the sole expressed hexokinase in hepatocellular carcinoma (HCC) cells

In clinical trials, doses are escalated gradually over several weeks to improve tolerability a process known as dose titration

J Clin Oncol 38(33):38413850 Miles D, Gligorov J, Andre F, Cameron D, Schneeweiss A, Barrios C et al (2021) Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line Paclitaxel with or without Atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer