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[DOI] [PMC free article] [PubMed] [Google Scholar] Grossoehme N

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PGE2) stimulates the production of multiple metalloproteases, resulting in breakdown of connective tissue inhibits the production of proteoglycans & type II collagen, exerting a global negative effect on joint cartilage stimulates the maturation of osteoclasts, which contributes to joint bone erosion Despite what is known about the contribution of IL-1 to the pathogenesis of RA, anakinra, a selective IL-1 antagonist has been found to be less effective than other biologics in the treatment of RA, which has limited its clinical use for this indication (Singh et al, 2009