The number of surviving bacteria was normalized to the untreated control (no Rif, no KL1 , Gen-only)
Notably, in TMZ-resistant LN229 cells, metformin suppressed key proteins, including mitochondrial transcription factor A, Twist, and O-6-methylguanine-DNA methyltransferase (MGMT) ( In summary, metformin disrupts the normal proliferation process of glioma cells and triggers apoptosis by activating the AMPK/mTOR signaling pathway, cell cycle arrest, mitochondria-dependent apoptosis pathway, inhibition of tumor cell metabolism, oxidative stress, and DNA damage, which provides a new idea for the treatment of glioma
Los datos disponibles provienen esencialmente de los estudios animales, donde el pptido ha mostrado generalmente un perfil de toxicidad muy favorable
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