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(2) poor antioxidant defense due to endogenous glutathione deficiency as a result of decreased biosynthesis and/or increased depletion of GSH [glutathione] is the most probable cause of increased oxidative damage of the lung, regardless which of the factors aging, chronic disease comorbidity, smoking or some others were responsible for this deficit. Many of the comorbid risk factors that predict severe COVID-19 disease are also tied to glutathione deficiency

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Frade J, Pope S, Schmidt M, Dringen R, Barbosa R, Pacock J, et al

61.9%, respectively) 34 and a post-hoc analysis of this trial showed a 6069% mean 10-years relative risk reduction of T2D development 75