glutathione conjugation in drug metabolism

glutathione conjugation in drug metabolism of S-Conjugates: Multiple Pathways Glutathione-Mediated Conjugation of Anticancer Drugs:

Name: glutathione conjugation in drug metabolism of S-Conjugates: Multiple Pathways Glutathione-Mediated Conjugation of Anticancer Drugs:
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[3] A number of reports show a reduction in adverse effects of chemotherapy when given concurrently with antioxidants

While this is a necessary first step, it frequently creates highly reactive, electrophilic intermediate metabolites that are actually more toxic and dangerous than the original parent compound

It can be given near the injury site or systemically

4,5,6 NADPH is also well known as an essential electron donor and an indispensable cofactor that is used for transferring and reserving reduction potential for numerous anabolic reactions