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It is clear that mitochondria-targeted therapies have demonstrated therapeutic efficacy in both cardiovascular disease and cognitive impairment, with some drugs already in clinical use while others remain in the early stages of research

So epithalon amidate is more stable than base epithalon, but its still vulnerable to about half of the relevant enzyme attack

464 A widely studied Ru(III) anticancer drug, KP1019 ( 60 ), reveals a unique anti-A strategy

Although not reported for Mito-tempo other mitochondria-targeted SOD mimetics such as Mito-CP have been shown to reduce hydrogen peroxide and the subsequent hydrogen peroxide-induced inactivation of complex I and aconitase in endothelial cells (von Montfort et al., 2012)