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The roGFPs, and particularly GRX1-roGFP2 fusion proteins, have been shown to sense the local E GSH with high specificity due to selective mediation of thiol/disulfide exchange reaction between glutathione and roGFP by GRXs (Meyer et al., 2007

mice that received Immunocal showed less decline in grip strength (a measure of the loss of muscle control that occurs as the disease progresses)

In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury (Fang et al., 2025)

Dickinson CJ