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"Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance." Diabetologia

While a high dietary intake of the vitamin rarely causes high vitamin B12, excess usually results from supplementation or injections

Patients with Multiple Endocrine Neoplasia syndrome type 2, a genetic condition associated with increased risk of medullary thyroid carcinoma, should also avoid treatment with this medication