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Report any suspected side effects to the MHRA via the Yellow Card Scheme at yellowcard.mhra.gov.uk

Primary Ovarian Insufficiency (POI): Also known as premature ovarian failure or premature menopause, this occurs when the ovaries stop functioning normally before the age of 40, leading to a decline in estrogen production and irregular or absent periods

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This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes