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It helps restore and maintain a healthy gut barrier, even under stress

In females, estrogen level fluctuates significantly across different physiological periods, with estradiol peaking during the menstrual cycle, estriol rising during pregnancy, and overall estrogen level declining during menopause, transitioning from ovarian to peripheral tissue production (25)

Crohn's disease, irritable bowel syndrome) in inflamed intestinal mucosa, little or no DAO can be produced and thus histamine cannot be broken down sufficiently