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Nowadays, molecular analysis, especially for doubtful patients, should rely on next generation sequencing (NGS) technologies, including multigene panels containing at least all EDS-associated genes and/or panels comprising genes of the major HCTDs in differential diagnosis and/or a custom phenotype-focused whole exome analysis [1]

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Nationally, the rate was 8.8%.2 Other tobacco product use: Wisconsin E-cigarette and smokeless tobacco use in Wisconsin In 2017, 4.3% of adults used e-cigarettes and 4.3% used smokeless tobacco.3 In 2017, 11.6% of high school students in Wisconsin used electronic vapor products on at least one day in the past 30 days

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