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Additionally, MT2A hinders cell growth via apoptosis and G2/M arrest, negatively influencing the NF-B pathway through upregulation of IB- and downregulation of p-IB- and cyclin D1 expression

Vital signs, ECGs, and physical exams showed no significant changes, and no cases of cancer or serious adverse events were reported over six months of follow-up [42]

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Key Findings: Asian participants: 21.3% mean weight loss with CagriSema (similar to overall population) Safety profile consistent across ethnicities GI tolerability similar but potentially lower discontinuation rates in Asian populations Clinical Significance: Supports global applicability of cagrilintide-based therapies across diverse populations