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On the other hand GPx3 is negatively correlated with MAPK oncogenic signaling pathway (94), which suggests a potential antitumor effect in thyroid cancer, while a decrease in GPx3 levels predisposes to an increase in the size of primary tumors and the number of metastatic lymph nodes (95, 96)

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155(3):10801090 Shiota M, Sugai N, Tamura M, Yamaguchi R, Fukushima N, Miyano T et al (2003) Correlation of mitogen-activated protein kinase activities with cell survival and apoptosis in porcine granulosa cells

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