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Coppen, A., Brooksbank, B

Common MCAS symptoms include: Extreme fatigue Flushing of the face Neck and cheek flushing Rashes Itching Lesions Headache that wont go away Heart palpitations Abdominal pain Bloating Diarrhea Vomiting Uterine cramps and bleeding Bone/muscle pain Cognitive dysfunction, including brain fog Lightheadedness Anxiety or depression In severe cases, the person becomes unable to breathe, walk, or otherwise function normally and may suffer a stroke, heart attack, or other life-threatening health situation

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Biologics like belimumab or anifrolumab have specific immune targets that could overlap with or be affected by peptide mechanisms