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10.1016/j.pharmthera.2020.107749 107 LinC

Important point #1

Significantly raises levels of NAD+, a molecule cells need for energy, by blocking an enzyme called NNMT

Mounting evidence suggests that ferroptosis liabilities are frequently imposed by the tumor microenvironment, metastatic niche and nutrient availability, implying that conventional in vitro models may underestimate therapeutic opportunities