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Thus, GPx4 is considered not only a phase II antioxidant enzyme but is also endowed with functions associated with the regulation of apoptosis, gene expression, eicosanoid biosynthesis, and embryo development (Imai and Nakagawa, Gpx4 gene in homozygous Gpx4 knockout causes in utero fetal death by midgestation (Imai et al., Gpx13 genes, which are viable though more sensitive to stressors (Brigelius-Floh and Maiorino, in vivo

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Modulation of host antioxidative system: possible role of microbial glutathione metabolism Glutathione has a widespread role in maintaining human health and upkeep of the immune system

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