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Key secondary sources include FDA Pre-Market Tobacco Application (PMTA) authorization database (2020-2025), CDC National Youth Tobacco Survey (NYTS) 2019-2023, ASH UK Annual E-Cigarette Use Survey (2024), WHO Report on the Global Tobacco Epidemic (2023), Global State of Tobacco Harm Reduction reports, Euromonitor International tobacco and vapor data, Statista e-cigarette revenue database, and trade publications including Vaping Post, and Tobacco Reporter

12 While there is much debate over the safety of e-cigarettes, several researchers have said that e-cigarettes should be used as harm-reduction because they do not contain as much tar and other harmful substances as cigarettes do

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Role of carbon monoxide in blood pressure regulation