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Since cellular senescence is considered a natural defense mechanism against tumor development, and senescence inductions triggered by currently applied therapies can significantly impact their effectiveness, it is assumed that purposeful stimulation of senescence in cancer cells may be a promising direction in the development of anticancer therapy [8, 15, 55]

Some designs draw inspiration from viruses, which can break through mucus because of their densely charged but neutral or slightly negative zeta potentials at physiological pH levels

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