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It highlights recent evidence that alcohol induces a cascade of reactive oxygen species (ROS)-mediated lipid peroxidation and nicotinamide adenine dinucleotide (NAD + ) depletion, triggering mitochondrial dysfunction and metabolic imbalances in the liver, heart, pancreas, and brain

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The sp 3 carbon scaffold of the pinane rings offered an effective way to capture interactions with the hydrophobic portions of subpocket C while also displacing likely trapped waters

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