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This coincides with the findings of Kan and Lau 27 study that found that only 18.9% of tobacco retailers complied with the law forbidding the sale of tobacco products to youth aged 10 RMB in the past 30 days, which was much higher than the proportion in adults (nearly 50%) 31

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However, whether CSE activates an MKK3/p38-dependent PRKN Ser131 phosphorylation axis to causally suppress PRKN-mediated mitophagy, thereby driving mtROS accumulation and epithelial senescence, has not been established in COPD-relevant models