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296 Inhibiting PDK1&2 reduces histone lactylation, alleviating PASMC proliferation and vascular remodeling in hypoxic pulmonary hypertension rats, suggesting the implication of lactate-lactylation in anti-remodeling therapy of pulmonary hypertension

1,8-Cineole pre-treatment at 100, 200, and 400 mg/kg orally inhibited the upregulation of IL-6, TNF-, and IL-1 levels due to cerulein induction, but IL-10 level was increased by 1,8-cineole (Lima et al., 2013)