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Indeed, alterations in CD4 + T-cell differentiation were recently found in the intestine of mice with mutations in the adenomatous polyposis coli ( Apc ) gene ( Apc +/Min and Apc +/1638N ), which, upon H

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In this context, research strategies aimed at the selective inhibition of FOXO proteins including the use of peptide analogs such as FOXO4-DRI represent a promising approach for investigating the modulation of metabolic pathways, with potential relevance to diabetes-related complications