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Respiratory system Rhinitis Nasal congestion Sneezing Rhinorrhea (nasal discharge) Dyspnea (difficult or labored breathing) Gastrointestinal system Nausea Vomiting Diarrhea Abdominal pain Constipation Bloating Feelings of fullness after eating any amount Nervous system Headache Dizziness Circulatory system Hypotonia (weakened muscle tone) Tachycardia (rapid heart rate) Collapse Skin Sudden facial erythema (flushing) Pruritus (itchy dry skin) Rashes Eczema Swelling Reproductive system Irregular periods in women What Causes Histamine Intolerance

J Biol Chem, 2002

Because methylation impacts so many systems, MTHFR gene mutation symptoms can vary widely

Systemic insulin resistance and intrahepatic triglyceride buildup have been shown to significantly decrease when dietary fructose intake is decreased[91]