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Notably, some muscle groups, especially the rectus abdominis, psoas major, and paraspinal muscles, reportedly showed more evident changes

It also modulates reward pathways in the brain, reducing food cravings particularly for high-fat and high-sugar foods

Fluorodeoxyglucose-PET imaging shows characteristic hypo-metabolism in the posterior cingulate cortex and precuneus in the early stages of Alzheimer's disease, with temporoparietal hypo-metabolism manifesting before structural changes [160]

In this study, researchers used a combination approach using blood samples and Artificial Intelligence (AI) where they identify circulating biomarkers in samples (CTCs, ctDNA, exosomes, circulating immune system, circulating cell-free nucleosomes, proteins, and microbiota) [66]