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However, survodutide Phase 3 trials use slower dose escalation, which may improve these numbers

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each R 4 is independently selected from F, Cl, Br, I, CN, NO 2 , CF 3 , OR 9 , OCF 3 , NR 8 R 9 , C(O)R 10 , CO 2 R 9 , C(O)NR 8 R 9 , N(R 8 )C(O)R 10 , N(R 8 )CO 2 R 10 , NHS(O) 2 R 10 , S(O) 2 NR 8 R 9 , C 3 -C 6 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, C 2 -C 7 heterocycloalkyl, C 6 -C 10 aryl, and C 3 -C 9 heteroaryl

Iraimoud S, Sttamato T, Mauldin S, Biaglow J et al