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on the supposed aggravation of COVID-19 ( more topical than ever ( The French Ministry of Health Olivier Veran embracing Micallefs hypothesis, warned the public to avoid NSAIDs like ibuprofen in case of SARS-CoV-2 infection ( On the other hand, the warning was immediately questioned ( Indeed, a closer view to NSAIDs pharmacodynamics might lead to opposite conclusions on their therapeutic value in SARS-CoV-2 infection

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This finding was first well established in women who are heterozygous for hypoxanthine phosphoribosyltransferase deficiency, and it has also been observed in several women heterozygous for severely deficient G6PD variants