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Although the metabolites released from hepatocytes after drug exposure and injury are only a part of the altered endometabolome, they can still serve as potential biomarkers for hepatotoxicity in vivo DILI studies, as recent research has demonstrated ( in vivo , is an incidentally used strategy for identifying hepatic toxicity biomarkers in different biological samples such as plasma, serum, urine, feces, or tissue biopsies

Pre-incubation and dilution assay GSTO1 (2 g) was incubated with inhibitor at a concentration of 10 IC 50 in a 10 l reaction volume for 30 min at 37 C

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