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doi: 10.3389/fnins.2017.00703 Received 10 July 2017 Accepted 30 November 2017 Published 12 December 2017 Volume 11 - 2017 Edited by Justin John Yerbury, University of Wollongong, Australia Reviewed by Mikhail Yu

MIN6 cells a mouse pancreatic 13-cell line were cultured in DMEM containing 5.6 mM glucose, 10% FBS, 100 g/ml streptomycin, 100 U/ml penicillin, and 50 M 13-mercaptoethanol at 37 C

IL-1 receptor antagonist (IL-1Ra) IL-1Ra, encoded by Il1rn , binds to IL-1R1 without inducing signaling pathways and prevents the binding of IL-1/ [148]

However, the mechanisms underlying this relationship remain unclear, and further studies are needed