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Kynurenine production insufficiency theory Recent research has identified the aryl hydrocarbon receptor (AhR) and the enzyme indoleamine-2,3-dioxygenase (IDO) as key players in the increased gut permeability and bacterial endotoxin translocation seen in ME/CFS patients

The identification of a novel protein kinase, not a second messenger-dependent protein kinase, with the ability to phosphorylate the agonist-occupied 2-AR, was a landmark in GPCR biology (Benovic et al ., 1986)