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It is particularly active in musculoskeletal and connective tissues

The likelihood of these symptoms significantly increases from Braak stages I/II to Braak stages III/IV ( Other NPS in AD encompass a range of behaviors and conditions, including sleep disturbances, circadian rhythm disruptions, prosopagnosia (difficulty recognizing faces), eating disorders (such as hyperphagia or lack of appetite), disinhibition (lack of self-control), hallucination (false sensory perception) and delusion (unshakably untrue belief)

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