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This imbalance creates an environment where ulcers can form, causing pain, nausea, and internal bleeding in severe cases

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Due to the downregulation of colonic CD4 T cell nAChRs controlled by IL-12, nicotine aggravated colonic inflammation with the development of wide-ranging mucosal cell death in the proximal colon, exhaustive crypt injury, entire goblet cell exhaustion, lamina propria ruination, and huge lymphocytic infiltration [62]

Camera AA, Tomaselli V, Fleming J, Jabbar GA, Trachtenberg M, Galvez-Buccollini JA, et al